Author

D. Lei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. M. Klimek-Abercrombie· 1 shared A. Szwed· 1 shared B. Fang· 1 shared C. B. Verchere· 1 shared C. H. Dohlman· 1 shared C. Zhou· 1 shared D. Vavvas· 1 shared D. Wu· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPathology

A. M. Klimek-Abercrombie

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Elevated islet prohormone ratios as indicators of insulin dependency in islet transplant recipients

Y.-C. Chen, A. M. Klimek-Abercrombie, K. J. Potter, L. P. Pallo, G. Soukhatcheva, D. Lei, M. Bellin, C. B. Verchere

The paper identifies elevated prohormone ratios as indicators of insulin dependency in islet transplant recipients using human and mouse models.

bioRxiv · Oct 17, 2021 · PreprintPathology

MEMS directed evolution of two cytochrome P450 enzymes revealing distinct active-sites for convergent function

L. Ma, F. Li, X. Zhang, H. Chen, Q. Huang, X. Liu, T. Sun, B. Fang, K. Liu, J. Chen, L. Yao, D. Wu, W. Zhang, D. Lei, S. Li

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

bioRxiv · Dec 25, 2020 · PreprintBiochemistry

Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries

E. I. Paschalis, D. Lei, C. Zhou, X. Chen, V. Kapoulea, P.-C. Hui, R. Dana, J. Chodosh, D. Vavvas, C. H. Dohlman

This study shows that microglia regulate neuroglia remodeling in ocular injuries, and their depletion leads to increased inflammation and retinal damage.

bioRxiv · Oct 8, 2018Immunology

3D images of Neuronal Adhesion Molecule Contactin-2 Reveal an Unanticipated Two-State Architecture

Z. Lu, D. Lei, S. Seshadrinathan, A. Szwed, J. Liu, J. Liu, G. Rudenko, G. Ren

This study uses 3D imaging to reveal the dynamic two-state architecture of the CNTN2 extracellular domain, showing it exists in equilibrium between closed and open conformations.

bioRxiv · Aug 6, 2018 · PreprintBiochemistry