Author

E. J. Kremer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

K. Eichholz· 3 shared O. Paris· 3 shared T. T. P. Tran· 3 shared C. Cheneau· 2 shared F. J. Mennechet· 2 shared M. Pugniere· 2 shared C. Henriquet· 1 shared C. Moyer· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

K. Eichholz

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Author profile →

4 papers

Recent·Most cited

Human innate lymphoid cell activation by adenoviruses is modified by host defence proteins and neutralizing antibodies

O. Paris, F. J. Mennechet, E. J. Kremer

This study shows that human innate lymphoid cells (ILCs) uptake adenoviruses and respond with cytokine secretion, and that host defense proteins and neutralizing antibodies modify this response.

bioRxiv · Jun 13, 2022 · PreprintImmunology

Adenovirus-α-defensin complexes induce NLRP3-associated maturation of human phagocytes via TLR4 engagement

K. Eichholz, H. T. Tran, C. Cheneau, T. T. P. Tran, O. Paris, M. Pugniere, E. J. Kremer

This study shows HNP-1 binds HAdV capsids, redirects them to TLR4, triggering NLRP3 inflammasome and IL-1β release in human phagocytes without membrane disruption.

bioRxiv · Oct 26, 2021Immunology

Lactoferrin retargets adenoviruses to TLR4 to induce an abortive NLRP3-associated pyroptotic response in human dendritic cells

C. Cheneau, K. Eichholz, T. H. Tran, T. T. P. Tran, O. Paris, C. Henriquet, M. Pugniere, E. J. Kremer

This study shows lactoferrin redirects adenoviruses to TLR4, triggering an abortive pyroptotic response in dendritic cells that releases pro-inflammatory cytokines.

bioRxiv · Jun 3, 2020Immunology

Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells

E. J. Kremer, T. T. P. Tran, K. Eichholz, P. Amelio, C. Moyer, G. R. Nemerow, M. Perreau, F. J. Mennechet

The paper shows that adenovirus-specific regulatory T cells are generated via tolerogenic dendritic cells induced by immunoglobulin-complexed adenoviruses.

bioRxiv · May 30, 2018Microbiology