CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer
H. Matsuoka, K. Ando, E. J. Swayze, E. C. Unan, J. Mathew, Q. Hu, Y. Tsuda, Y. Nakashima, H. Saeki, E. Oki, A. K. Bharti, M. Mori
This study shows that rabeprazole inhibits CTDSP1, which promotes irinotecan resistance in colorectal cancer by enhancing DNA-PKcs-mediated topoisomerase I degradation.
bioRxiv · Jan 7, 2020Cancer Biology