Author

H. Saeki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. Oki· 2 shared A. Imai· 1 shared A. K. Bharti· 1 shared A. Sen· 1 shared D. Miura· 1 shared E. C. Unan· 1 shared E. J. Swayze· 1 shared E. Miyauchi· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

E. Oki

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line by stimulated with live probiotic bacteria

A. Sen, A. Imai, E. Miyauchi, K. Yanagisawa, T. Oda, F. Sasaki, S. Uchida, T. Okada, T. Yokobori, H. Saeki, T. Odamaki, N. Sasaki

The paper compares gene expression in healthy human colonic organoid cells and cancer cell lines after coculture with probiotic bacteria, identifying distinct gene signatures and functional changes.

bioRxiv · May 23, 2024Ecology

CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer

H. Matsuoka, K. Ando, E. J. Swayze, E. C. Unan, J. Mathew, Q. Hu, Y. Tsuda, Y. Nakashima, H. Saeki, E. Oki, A. K. Bharti, M. Mori

This study shows that rabeprazole inhibits CTDSP1, which promotes irinotecan resistance in colorectal cancer by enhancing DNA-PKcs-mediated topoisomerase I degradation.

bioRxiv · Jan 7, 2020Cancer Biology

DNA replication stress induced by trifluridine determines tumor cell fate according to p53 status

Y. Kataoka, M. Iimori, R. Fujisawa, T. Morikawa-Ichinose, S. Niimi, T. Wakasa, H. Saeki, E. Oki, D. Miura, T. Tsurimoto, Y. Maehara, H. Kitao

This paper shows that trifluridine induces DNA replication stress that leads to different cell fates in tumor cells depending on their p53 status.

bioRxiv · Sep 13, 2019Cancer Biology