ADAM10 tailors extracellular vesicles for content transfer rather than signaling by contact
Rania Ghossoub, Laurent Goullieux, Stéphane Audebert, Lukáš Hyka, E. Jaafar, Samuel Granjeaud, M. Methia, Sylvie Thuault, Raphaël Leblanc, Guido David, Pascale Zimmermann
The paper shows ADAM10 regulates sEV composition and signaling by cleaving receptors and sorting proteins, shifting sEVs from content delivery to contact-dependent signaling.
bioRxiv · Feb 16, 2026 · PreprintCell Biology