Stéphane Audebert

A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria

The paper reports a large-scale quantitative interactome of human PDZ domains and bacterial PDZ-binding motifs, showing bacteria tailor effector sequences to bind with similar or higher affinity than human PBMs to hijack host functions.

The atypical cadherin CELSR2 regulates distinct epithelial-mesenchymal states and oxidative phosphorylation in triple-negative breast cancer

This study identifies CELSR2 as a regulator of epithelial-mesenchymal plasticity and oxidative phosphorylation in triple-negative breast cancer, showing its role in shaping tumor heterogeneity.

Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstream

The paper identifies PTK7 as a marker for colorectal cancer cell plasticity and metastatic potential, showing its loss in circulating tumor cells enables stress resistance and metastasis through surfaceome remodeling.

Cardiolipin constrains lipid unsaturation during anaerobic adaptation in Escherichia coli

This study investigates how cardiolipin influences lipid unsaturation and membrane function during anaerobic adaptation in E. coli, revealing its role in optimizing membrane protein function.

PSMD14 drives melanoma cell survival and MAPK inhibitor resistance through histone H2A deubiquitination

This study identifies PSMD14 as a key driver of melanoma survival and resistance to MAPK inhibitors by deubiquitinating histone H2A, altering chromatin state and gene expression.

ADAM10 tailors extracellular vesicles for content transfer rather than signaling by contact

The paper shows ADAM10 regulates sEV composition and signaling by cleaving receptors and sorting proteins, shifting sEVs from content delivery to contact-dependent signaling.

Non-canonical TERT function mitigates adipose tissue inflammation in obesity by modulating stem cell-macrophage communication and macrophage states

This study shows that TERT expression in adipose tissue reduces inflammation and improves metabolism in obesity by altering macrophage states and stem cell-macrophage communication.

TTLL6-mediated Polyglutamylation of PurA Maintains Colonic Crypt Integrity

This study identifies TTLL6 as a key polyglutamylase in the colon, showing its role in maintaining crypt integrity and preventing colon cancer progression.

Identification of AB8939, a novel synthetic microtubule destabilizer and ALDH inhibitor that overcomes multidrug resistance in tumor cells as a drug candidate for the treatment of refractory acute myeloid leukemia

This paper identifies AB8939, a novel drug that targets microtubules and ALDH enzymes, showing efficacy against drug-resistant AML cells and models.

A systematic interactome of SET1C expands its functional landscape and identifies candidate regulatory connections

The paper identifies new interactors of the SET1C complex through yeast two-hybrid screens, revealing its roles in chromatin regulation, RNA biogenesis, and nuclear transport.

USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

This study identifies USP9X as a mechanosensitive deubiquitinase that stabilizes YAP to enhance tumor cell invasiveness and drug resistance.

Deciphering the dynamic proteome of multiciliated cells

This study generates a stable MCC line to profile proteome dynamics during differentiation, identifying CDK7 as a critical regulator in Xenopus and human systems.

SLX4 dampens MutSα-dependent mismatch repair

This study identifies a novel function of SLX4 in inhibiting MutSα-dependent mismatch repair through its interaction with MSH2.

UFMylation of MRE11 is essential for telomere length and hematopoietic stem cell survival

The paper identifies UFMylation of MRE11 as critical for telomere length and hematopoietic stem cell survival, showing its role in telomere maintenance without affecting DNA repair.

Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry

The paper shows that Toll-8 and Cirl GPCRs form an asymmetric complex to polarize Myosin-II, driving planar cell intercalations during Drosophila embryonic axis extension.

Integrative proteomic and phosphoproteomic profiling of prostate cell lines

This study profiles the proteomes and phosphoproteomes of four prostate cell lines to identify differentially expressed proteins and phosphosites associated with resistance and cancer progression.