Author

E. K. LaVigne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

E. P. S. Pratt· 2 shared G. H. Hockerman· 2 shared K. E. Harvey· 2 shared A. E. Salyer· 1 shared H. Gowher· 1 shared M. S. Dar· 1 shared P. A. Sample· 1 shared S. Tang· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

E. P. S. Pratt

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2 papers

Recent·Most cited

RyR2 regulates store-operated Ca2+ entry, phospholipase C activity, and electrical excitability in the insulinoma cell line INS-1

K. E. Harvey, S. Tang, E. K. LaVigne, E. P. S. Pratt, G. H. Hockerman

This study shows RyR2 regulates SOCE, PLC activity, and electrical excitability in INS-1 cells by modulating PIP2 levels and Cav channel currents.

bioRxiv · Oct 19, 2022Cell Biology

RyR2/IRBIT regulates insulin gene transcription, insulin content, and secretion in the insulinoma cell line INS-1

K. E. Harvey, E. K. LaVigne, M. S. Dar, E. P. S. Pratt, A. E. Salyer, P. A. Sample, U. K. Aryal, H. Gowher, G. H. Hockerman

Deletion of RyR2 or IRBIT in INS-1 cells reduces insulin content and secretion, with RyR2 also decreasing IRBIT levels and affecting DNA methylation and proteome regulation.

bioRxiv · Nov 24, 2021Cell Biology