Mice deficient of Myc super-enhancer region reveal a differential control mechanism between normal and pathological growth
K. Dave, I. Sur, J. Yan, J. Zhang, E. Kaasinen, F. Zhong, L. Blaas, X. Li, R. Mansson, J. Taipale
This study shows that deleting the Myc super-enhancer region in mice reduces Myc expression and tumor susceptibility without overt phenotypes, suggesting therapeutic potential for targeting this element in cancer.
bioRxiv · Oct 24, 2016Cancer Biology