F. Zhong

Structural analysis of the dynamic ribosome-translocon complex

The paper uses cryo-EM and structure prediction to analyze new configurations of the ribosome-translocon complex, revealing dynamic interactions during protein biogenesis.

Direct measurements of collagen fiber recruitment in the posterior pole of the eye

This paper directly measures collagen fiber recruitment in the peripapillary sclera and lamina cribrosa under stretch, finding sigmoidal recruitment curves with PPS recruiting faster and at lower stretch than LC.

Ultra-high-speed multi-parametric photoacoustic microscopy

This paper develops an ultra-high-speed multi-parametric photoacoustic microscopy system for real-time monitoring of blood parameters in awake mice.

Structural basis of main proteases of coronavirus bound to drug candidate PF-07321332

This study reports crystal structures of SARS-CoV-2, SARS-CoV, and MERS-CoV main proteases bound to PF-07321332, revealing conserved ligand-binding sites and insights into inhibitor mechanism.

A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography

This paper introduces a high-accuracy and high-efficiency digital volume correlation method to analyze in-vivo optic nerve head biomechanics from OCT data, showing improved performance over conventional methods.

Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin

The paper reports the crystal structure of SARS-CoV-2 main protease bound to shikonin, revealing conformational changes and binding modes that could inform drug design.

Structure of SARS-CoV-2 main protease in the apo state reveals the inactive conformation

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin

This paper identifies an Anr-regulated hemerythrin, Mhr, that enhances fitness of Pseudomonas aeruginosa lasR mutants in microoxic conditions by binding oxygen.

A general quantitative relation linking bacterial cell growth and the cell cycle

This study challenges two established dogmas about bacterial cell growth and reveals a new linear relation between cell mass and division count across a wide range of growth rates in E. coli.

Endodermal differentiation is reconstructed by coordination of two parallel signaling systems derived from the stele in roots

The paper demonstrates that SHR and stele-derived small peptides coordinate to rebuild functional Casparian strips in non-endodermal cells through two parallel signaling systems.

Mice deficient of Myc super-enhancer region reveal a differential control mechanism between normal and pathological growth

This study shows that deleting the Myc super-enhancer region in mice reduces Myc expression and tumor susceptibility without overt phenotypes, suggesting therapeutic potential for targeting this element in cancer.