SLC4A2 Anion Exchanger Promotes Tumor Cell Malignancy via Enhancing H+ Leak across Golgi Membranes
E. Khosrowabadi, A. Rivinoja, M. Risteli, A. Tuomisto, T. Salo, M. Makinen, S. Kellokumpu
This study identifies SLC4A2 as a driver of tumor malignancy by enhancing H+ leak across Golgi membranes, leading to elevated Golgi pH and reduced glycosylation, which can be reversed by AE2 knockdown.
bioRxiv · Feb 9, 2021Cancer Biology