The level of oncogenic Ras controls the malignant transformation of Lkb1 mutant tissue in vivo.
B. Rackley, C.-S. Seong, E. Kiely, R. E. Parker, M. Rupji, B. Dwivedi, J. M. Heddleston, W. Giang, N. Anthony, T.-L. Chew, M. Gilbert-Ross
A Drosophila model shows that high oncogenic Ras levels drive malignant transformation in Lkb1 mutant tissue, with implications for human lung adenocarcinoma.
bioRxiv · Sep 25, 2020Cancer Biology