Author

J. M. Heddleston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:imaging· 5 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Approach:microscopy & imaging analysis· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

T.-L. Chew· 3 shared A. Balabiyev· 1 shared A. C. I. van Steen· 1 shared A. Ciccarelli· 1 shared A. M. Dowbaj· 1 shared B. Dwivedi· 1 shared B. Rackley· 1 shared C. T. Black· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

T.-L. Chew

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

J. J. G. Arts, E. K. Mahlandt, M. Grönloh, L. Schimmel, I. Noordstra, A. C. I. van Steen, S. Tol, J. van Rijssel, M. A. Nolte, M. Postma, S. Khuon, J. M. Heddleston, E. Wait, T. L. Chew, M. Winter, , J. D. van Buul

The paper identifies endothelial junctional membrane protrusions as preferred sites for neutrophil transmigration during inflammation and shows they depend on Rac1 activity.

bioRxiv · Jan 18, 2021Cell Biology

The level of oncogenic Ras controls the malignant transformation of Lkb1 mutant tissue in vivo.

B. Rackley, C.-S. Seong, E. Kiely, R. E. Parker, M. Rupji, B. Dwivedi, J. M. Heddleston, W. Giang, N. Anthony, T.-L. Chew, M. Gilbert-Ross

A Drosophila model shows that high oncogenic Ras levels drive malignant transformation in Lkb1 mutant tissue, with implications for human lung adenocarcinoma.

bioRxiv · Sep 25, 2020Cancer Biology

An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling

A. M. Dowbaj, R. P. Jenkins, J. M. Heddleston, A. Ciccarelli, T. Fallesen, K. Hahn, M. Montagner, E. M. Sahai

This paper introduces an optogenetic method to measure nuclear-cytoplasmic shuttling rates of YAP1 and TAZ, showing phosphorylation enhances nuclear export and that import/export rates are correlated within cells.

bioRxiv · Jun 8, 2020Cell Biology

Quantitative measurements of chromatin modification dynamics during zygotic genome activation

Y. Sato, L. Hilbert, H. Oda, Y. Wan, J. M. Heddleston, T.-L. Chew, V. Zaburdaev, P. Keller, T. Lionnet, N. Vastenhouw, H. Kimura

The paper quantifies chromatin modification dynamics during zygotic genome activation in zebrafish embryos using fluorescent antibody imaging.

bioRxiv · Apr 6, 2019 · PreprintCell Biology

An actin-based protrusion originating from a podosome-enrichedregion initiates macrophage fusion

J. J. Faust, A. Balabiyev, J. M. Heddleston, N. P. Podolnikova, D. P. Baluch, T.-L. Chew, T. Ugarova

This study identifies actin-based protrusions from podosome-enriched regions as initiators of macrophage fusion in chronic inflammatory diseases.

bioRxiv · Feb 4, 2019Cell Biology

Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells

F. Tamzalit, M. S. Wang, W. Jin, V. Boyko, J. M. Heddleston, C. T. Black, L. C. Kam, M. Huse

Cytotoxic T cells use actin-rich protrusions at immunological synapses to enhance perforin and granzyme-mediated killing of target cells.

bioRxiv · Oct 14, 2018Immunology