Membrane-proximal external region is a superior target for mediating effector activity of HIV-1 specific chimeric antigen receptor modified T cells.
M. Kamata, E. Kranz, J. Chan, H. Wang, M. Hashimoto, T. Kanazawa
This paper develops a multicolor flow cytometry assay to compare anti-HIV-1 activity of different CAR constructs and identifies that CARs targeting the membrane-proximal external region show higher cytotoxicity than CD4{zeta} CAR.
bioRxiv · Mar 11, 2020 · PreprintMicrobiology