MYC-driven epigenetic reprogramming favors the onset of tumorigensis by inducing a stem cell-like state
V. Poli, L. Fagnocchi, A. Fasciani, A. Cherubini, S. Mazzoleni, S. Ferrillo, A. Miluzio, G. Gaudioso, V. Vaira, A. Turdo, M. Giaggianesi, A. Chinnici, E. Lipari, S. Bicciato, S. Bosari, , A. Zippo
This study shows MYC induces an epigenetic reprogramming in mammary epithelial cells that promotes a stem cell-like state and tumor initiation in breast cancer.
bioRxiv · Dec 29, 2017Cancer Biology