Author

L. Fagnocchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

E. Dror· 3 shared I. Panzeri· 3 shared J. A. Pospisilik· 3 shared S. Apostle· 3 shared A. Drougard· 2 shared V. Wegert· 2 shared A. Bergsma· 1 shared A. Bremser· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

E. Dror

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Developmental priming of cancer susceptibility

I. Panzeri, L. Fagnocchi, S. Apostle, M. Tompkins, E. Wolfrum, Z. Madaj, G. Hostetter, Y. Liu, K. Schaefer, C.-H. Yang, A. Bergsma, A. Drougard, E. Dror, PERMUTE, D. Chandler, , J. A. Pospisilik

The paper shows that early life epigenetic variation can prime cancer-susceptibility states that persist into adulthood and correlate with poor prognosis in human cancers.

Nature Cancer · Jan 24, 2025Peer-reviewedCancer Biology

An acute microglial metabolic response controls metabolism and improves memory

A. Drougard, E. H. Ma, V. Wegert, R. Sheldon, I. Panzeri, N. Vatsa, S. Apostle, L. Fagnocchi, J. Schaf, K. Gossens, J. Völker, S. Pang, A. Bremser, E. Dror, F. Giacona, , J. A. Pospisilik

The paper identifies an acute microglial metabolic response to high-fat diet that improves metabolism and memory by converting harmful fatty acids into beneficial metabolites.

bioRxiv · Apr 3, 2023Physiology

Identification of two β-cell subtypes by 7 independent criteria

E. Dror, L. Fagnocchi, V. Wegert, S. Apostle, B. Grimaldi, T. Gruber, I. Panzeri, S. Heyne, K. D. Hoeffler, V. Kreiner, R. Ching, T. T.-H. Lu, A. Semwal, B. Johnson, P. Senapati, , J. A. Pospisilik

The paper identifies two distinct β-cell subtypes, βHI and βLO, using seven independent criteria and shows that H3K27me3 dosage regulates their ratio in vivo.

bioRxiv · Jan 31, 2023Cell Biology

MYC-driven epigenetic reprogramming favors the onset of tumorigensis by inducing a stem cell-like state

V. Poli, L. Fagnocchi, A. Fasciani, A. Cherubini, S. Mazzoleni, S. Ferrillo, A. Miluzio, G. Gaudioso, V. Vaira, A. Turdo, M. Giaggianesi, A. Chinnici, E. Lipari, S. Bicciato, S. Bosari, , A. Zippo

This study shows MYC induces an epigenetic reprogramming in mammary epithelial cells that promotes a stem cell-like state and tumor initiation in breast cancer.

bioRxiv · Dec 29, 2017Cancer Biology