S. Bicciato

ETV7 reduces inflammatory responses in breast cancer cells by repressing TNFR1/NF-kappaB axis

This study shows ETV7 reduces inflammation in breast cancer by suppressing TNFR1 and NF-kappaB signaling through direct gene repression and competition with STAT3.

SiglecFhigh neutrophils in lung tumor tissues suppress local CD8 T cell responses and limit the efficacy of anti PD-L1 antibodies

This study shows that SiglecFhigh neutrophils in lung tumors suppress CD8 T cell responses and reduce the effectiveness of anti-PD-L1 therapy.

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

The paper shows that glycolysis downregulation is a hallmark of HIV-1 latency and that targeting antioxidant pathways can reactivate latent HIV-1.

Mutated clones driving leukemic transformation are already detectable at the single cell level in CD34-positive cells in the chronic phase of primary myelofibrosis

The paper uses single cell genomics and transcriptomics to analyze CD34-positive cells in a PMF patient, identifying early mutations and clonal evolution associated with AML transformation.

EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells

This study identifies EphB6 as a regulator of the TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells in a foreign environment.

ETV7 regulates breast cancer stem-like cell plasticity by repressing IFN-response genes

This study shows ETV7 promotes breast cancer stem-like cell plasticity and resistance to chemotherapy and radiotherapy by repressing IFN-response genes, which may be reversible with IFN-β treatment.

MYC-driven epigenetic reprogramming favors the onset of tumorigensis by inducing a stem cell-like state

This study shows MYC induces an epigenetic reprogramming in mammary epithelial cells that promotes a stem cell-like state and tumor initiation in breast cancer.