Molecular basis of mitotic decline during human aging
J. C. Macedo, S. Vaz, B. Bakker, R. Ribeiro, P. Bakker, J. M. Escandell, M. G. Ferreira, R. Medema, F. Foijer, E. Logarinho
This study identifies aneuploidy as a driver of mitotic decline in aging by showing FoxM1 repression leads to chromosome segregation defects and senescence.
bioRxiv · Feb 6, 2018Cell Biology