B. Bakker

Tracking genome evolution in single cell clones reveals the rates and features of copy number alterations generated by ongoing chromosomal instability in cancer.

The paper tracks genome evolution in single-cell clones to reveal copy number alteration rates and features in cancer driven by chromosomal instability.

Predicting CIN rates from single-cell whole genome sequencing data using an in silico model

The paper develops an in silico model, CINsim, to predict chromosomal instability (CIN) rates from single-cell whole genome sequencing data by simulating karyotype dynamics and validating it in mouse and human cancer models.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stability

This study investigates how different aneuploidies affect chromosomal instability in human cells, finding that trisomies increase segregation errors while monosomies do not induce CIN.

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

This study compares chronic and transient chromosomal instability in mice, showing that transient instability accelerates tumor formation through rapid clonal evolution.

Single cell DNA sequencing reveals distinct molecular types of basal cell carcinoma with unique transcriptome features

This study uses single-cell DNA sequencing to identify distinct molecular types of basal cell carcinoma based on karyotype heterogeneity and associated transcriptome features.

Non-Random Mis-Segregation of Human Chromosomes.

The paper shows that human chromosome mis-segregation is non-random, with specific chromosomes showing higher rates of aneuploidy due to cohesion fatigue.

Molecular basis of mitotic decline during human aging

This study identifies aneuploidy as a driver of mitotic decline in aging by showing FoxM1 repression leads to chromosome segregation defects and senescence.