Author

R. Medema

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Barrera· 1 shared A. Cvrljevic· 1 shared A. Gonzalez Manjon· 1 shared A. Huber· 1 shared A. Janssen· 1 shared A. Laine· 1 shared A. Quirindongo· 1 shared A. Teixeira· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

A. Barrera

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis

A. Laine, S. Nagelli, C. Farrington, U. Butt, A. Cvrljevic, J. Vainonen, T. Gronroos, P. Gautam, S. Khan, H. Sihto, X. Qiao, D. Connolly, P. Kronqvist, J. Maurer, K. Wennerberg, , J. Westermarck

This study identifies CIP2A as a subtype-specific driver of DNA damage-induced basal-like breast cancer, showing its role in checkpoint signaling and therapeutic vulnerability.

bioRxiv · Aug 27, 2020Cancer Biology

Degree and site of chromosomal instability define its oncogenic potential

W. Hoevenaar, A. Janssen, A. Quirindongo, H. Ma, S. Klaasen, A. Teixeira, J. Offerhaus, R. Medema, G. Kops, N. Jelluma

This study shows that chromosomal instability (CIN) can drive early-onset intestinal adenomas, with varying effects depending on CIN levels and tissue site.

bioRxiv · Dec 15, 2019Cancer Biology

Glucocorticoids regulate cancer cell dormancy

S. Prekovic, K. Schuurman, A. Gonzalez Manjon, M. Buijs, I. Mayayo Peralta, M. D. Wellenstein, S. Yavuz, A. Barrera, K. Monkhorst, A. Huber, B. Morris, C. Lieftink, J. Silva, B. Györffy, L. Hoekman, , W. Zwart

This study identifies the mechanism by which glucocorticoid receptor activation induces cancer cell dormancy through CDKN1C and FOXO1/IRS2 signaling, with implications for cancer therapy.

bioRxiv · Sep 4, 2019 · PreprintCancer Biology

Molecular basis of mitotic decline during human aging

J. C. Macedo, S. Vaz, B. Bakker, R. Ribeiro, P. Bakker, J. M. Escandell, M. G. Ferreira, R. Medema, F. Foijer, E. Logarinho

This study identifies aneuploidy as a driver of mitotic decline in aging by showing FoxM1 repression leads to chromosome segregation defects and senescence.

bioRxiv · Feb 6, 2018Cell Biology