RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion
W. Fic, R. Bastock, F. Raimondi, E. Los, Y. Inoue, J. Gallop, R. B. Russell, D. St Johnston
The paper identifies RhoGAP19D as a Cdc42 GTPase Activating Protein that restricts Cdc42 activity to the apical domain, preventing epithelial invasion.
bioRxiv · Sep 17, 2020Cell Biology