Author

S. B. Rothbart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

A. Kupai· 2 shared B. M. Dickson· 2 shared A. A. Chomiak· 1 shared A. K. Francois· 1 shared A. L. Whitford· 1 shared A. Lewis· 1 shared A. R. Cliffe· 1 shared A. Rohani· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

A. Kupai

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Author profile →

5 papers

Recent·Most cited

Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts

A. K. Francois, A. Rohani, M. S. Loftus, S. A. Dochnal, J. Hrit, S. McFarlane, A. L. Whitford, A. Lewis, P. A. Krakowiak, C. Boutell, S. B. Rothbart, D. Kashatus, A. R. Cliffe

This study investigates the association of HSV-1 genomes with H3K27me2 and PHF20L1 in fibroblasts, finding that H3K27me2 is linked to genome silencing and that this association is influenced by demethylase activity and transcriptional state.

mBio · Apr 10, 2024Peer-reviewedMicrobiology

Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving calcium-calcineurin-NFAT signaling

A. A. Chomiak, R. Tiedemann, Y. Liu, X. Kong, Y. Cui, K. Thurlow, E. M. Cornett, M. J. Topper, S. Baylin, S. B. Rothbart

The paper shows that combining DNMT inhibitors with selective EZH2 inhibitors enhances antiproliferative effects in colon cancer by modulating calcium-calcineurin-NFAT signaling and viral mimicry.

bioRxiv · Jun 9, 2023Cancer Biology

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

K. M. Luda, S. M. Kitchen-Goosen, E. H. Ma, M. J. Watson, L. R. Duimstra, B. M. Oswald, J. Longo, Z. Fu, Z. Madaj, A. Kupai, B. M. Dickson, I. Kaymak, K. Lau, S. Compton, L. M. DeCamp, , R. G. Jones

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

bioRxiv · Aug 26, 2022 · PreprintImmunology

Theoretical and practical refinements of sans spike-in quantitative ChIP-seq with application to p300/CBP inhibition

B. M. Dickson, A. Kupai, R. M. Vaughan, S. B. Rothbart

This paper refines siQ-ChIP to provide a simplified quantitative scale for ChIP-seq and applies it to study p300/CBP inhibition effects on genomic regions.

bioRxiv · Aug 9, 2022Biophysics

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

J. Kernan, R. C. Martinez-Chacin, X. Wang, R. L. Tiedemann, T. Bonacci, R. Choudhury, D. Bolhuis, J. S. Damrauer, F. Yan, J. S. Harrison, M. B. Major, K. Hoadley, A. Suzuki, S. B. Rothbart, N. G. Brown, M. J. Emanuele

The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.

bioRxiv · Apr 9, 2020Cell Biology