Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence.
S. Consalvi, L. Tucciarone, E. Macri, M. De Bardi, M. Picozza, I. Salvatori, A. Renzini, S. Valente, A. Mai, V. Moresi, P. L. Puri
This study shows that HDAC inhibitors are less effective in late-stage DMD muscle FAPs due to senescence-related epigenetic changes that resist reversal.
bioRxiv · Apr 26, 2021 · PreprintPharmacology & Toxicology