S. Valente

Inhibition of the macrophage demethylase LSD1 reverses Leishmania amazonensis-induced transcriptomic changes and causes a decrease in parasite load

This study shows that inhibiting LSD1 in macrophages reduces Leishmania parasite load and reverses infection-induced transcriptomic changes.

Lipid droplets 3D full measurement by holographic in-flow tomography

This paper introduces a new method for 3D characterization of lipid droplets in cells using holographic in-flow tomography, enabling high-throughput analysis and improved spatial understanding.

Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 Entry

This study identifies small molecule inhibitors of SARS-CoV-2 entry through high-throughput screening and validates Calpeptin as a potent inhibitor of SARS-CoV-2 and some variants.

Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence.

This study shows that HDAC inhibitors are less effective in late-stage DMD muscle FAPs due to senescence-related epigenetic changes that resist reversal.

No evidence for prolactin's involvement in the post-ejaculatory refractory period

This study investigates whether prolactin influences the post-ejaculatory refractory period in mice and finds no evidence supporting its involvement.

The role of high cholesterol in age related COVID19 lethality.

This study shows high cholesterol enhances SARS-CoV-2 entry and infectivity by promoting ACE2 and furin localization, contributing to COVID19 severity in elderly and obese individuals.

Histological evidences of diabetic kidney disease precede clinical diagnosis

The paper finds that diabetic kidney disease can be histologically diagnosed in normoalbuminuric diabetic patients without clinical signs of kidney disease.