L. Tucciarone

Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence.

This study shows that HDAC inhibitors are less effective in late-stage DMD muscle FAPs due to senescence-related epigenetic changes that resist reversal.

Pharmacological tuning of microRNA in FAP-derived Extracellular Vesicles by HDAC inhibitors promotes regeneration and reduces fibrosis in dystrophic muscles.

The paper shows that HDAC inhibitors increase microRNA levels in FAP-derived EVs, enhancing muscle regeneration and reducing fibrosis in dystrophic models.