PIKfyve inhibition reveals a novel role for Inpp4b in the regulation of PtdIns(3)P and lysosome dynamics
G. T. Saffi, E. Mangialardi, J. Vacher, R. J. Botelho, L. SALMENA
This study identifies a novel crosstalk between Inpp4b and PIKfyve that regulates lysosome membrane phosphoinositide composition and homeostasis by restricting VPS34-dependent PtdIns(3)P production.
bioRxiv · Dec 13, 2021Cell Biology