Author

G. T. Saffi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

L. SALMENA· 3 shared R. J. Botelho· 3 shared J. Vacher· 2 shared A. Fountain· 1 shared A. He· 1 shared A. Rashid· 1 shared C. A. Newell· 1 shared C. J. Guidos· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCell Biology

L. SALMENA

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PIKfyve inhibition reveals a novel role for Inpp4b in the regulation of PtdIns(3)P and lysosome dynamics

G. T. Saffi, E. Mangialardi, J. Vacher, R. J. Botelho, L. SALMENA

This study identifies a novel crosstalk between Inpp4b and PIKfyve that regulates lysosome membrane phosphoinositide composition and homeostasis by restricting VPS34-dependent PtdIns(3)P production.

bioRxiv · Dec 13, 2021Cell Biology

Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition

G. T. Saffi, E. Tang, S. Inpanathan, S. Mamand, A. Fountain, L. Salmena, R. J. Botelho

This study shows that reactive oxygen species (ROS) prevent lysosome coalescence during PIKfyve inhibition through distinct mechanisms depending on the ROS type.

bioRxiv · Jun 17, 2021Cell Biology

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

J. F. Woolley, K. Chen, G. T. Saffi, G. E. Genc, D. K. C. Lee, I. Dzneladze, R. He, J. T.-S. Chow, M. M. Gabra, M. H. Son, C. M. P. Melo, C. A. Newell, A. He, E. M. Schoof, S. Z. Xie, , L. Salmena

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

bioRxiv · Mar 25, 2021 · PreprintCancer Biology