Machupo virus with mutations in the transmembrane domain and glycosylation sites is attenuated and immunogenic in animal models of Bolivian Hemorrhagic Fever
E. Mantlo, J. Maruyama, J. T. Manning, T. G. Wanninger, C. Huang, J. N. Smith, M. Patterson, S. Paessler, T. Koma
This paper attenuates Machupo virus by mutating glycosylation sites and a transmembrane domain residue, showing attenuation in animal models and protective efficacy against wild-type virus.
bioRxiv · Dec 2, 2021 · PreprintMicrobiology