Author

E. McCallion

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

E. R. Sutton· 2 shared J. M. Hoolachan· 2 shared M. Bowerman· 2 shared M. J. Wood· 2 shared M. Okoh· 2 shared A. Bhomra· 1 shared A. J. Kordala· 1 shared C. Raoul· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPathology

E. R. Sutton

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2 papers

Recent·Most cited

Exercise and disease state influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model

G. Hazell, N. Ahlskog, E. R. Sutton, M. Okoh, J. M. Hoolachan, T. Scaife, S. Iqbal, E. McCallion, A. Bhomra, A. J. Kordala, F. Scamps, C. Raoul, M. J. Wood, M. Bowerman

This study shows that Fn14-depletion improves survival and muscle pathology in SOD1G93A ALS mice, but only when combined with exercise.

bioRxiv · Jul 5, 2024 · PreprintPathology

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models

J. M. Hoolachan, E. McCallion, E. R. Sutton, O. Cetin, P. Pacheco-Torres, M. Dimitriadi, M. Okoh, L. M. Walter, P. Claus, M. J. Wood, D. P. Tonge, M. Bowerman

The paper identifies 580 drug candidates with similar activities to prednisolone in SMA models using transcriptomics and drug repositioning, but only some show potential as SMA treatments.

bioRxiv · Jun 14, 2023Pathology