P. Claus

Bottom-up reconstruction of minimal pyrenoids provides insights into the evolution and mechanisms of carbon concentration by EPYC1 proteins

The paper reconstructs minimal pyrenoids using EPYC1 proteins to study their evolution and carbon concentration mechanisms.

Form IF Rubiscos include highly active, specific, and small subunit-independent enzymes.

The paper identifies Form IF Rubiscos that are highly active, specific, and function without the small subunit, challenging the necessity of subunit complexity in Rubisco evolution.

Precision sampling of discrete sites identified during in-vivo functional testing in the mammalian heart

The paper develops a 3D-printed targeted sampling method to accurately identify and study arrhythmogenic sites in the mammalian heart after myocardial infarction.

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models

The paper identifies 580 drug candidates with similar activities to prednisolone in SMA models using transcriptomics and drug repositioning, but only some show potential as SMA treatments.

Dysregulation of the Tweak/Fn14 pathway in skeletal muscle of spinal muscular atrophy mice

This study investigates the TWEAK/Fn14 pathway dysregulation in SMA mouse models and shows its role in muscle pathology and potential therapeutic intervention.

Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice

This study tests if muscle-specific Klf15 overexpression via AAV8 improves SMA mouse survival, finding limited efficacy in some models.