M. J. Wood

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models

The paper identifies 580 drug candidates with similar activities to prednisolone in SMA models using transcriptomics and drug repositioning, but only some show potential as SMA treatments.

HOIL1 regulates group 3 innate lymphoid cell numbers in the colon and protects against systemic dissemination, colonic ulceration, and lethality from Citrobacter rodentium infection

This study shows HOIL1 is critical for limiting C. rodentium infection by regulating ILC3 numbers and inflammatory responses in mice.

Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice

This study examines age-related changes in knee osteoarthritis, pain behaviors, and dorsal root ganglia immune profiles in male and female mice, revealing sex-specific differences in cartilage degeneration and immune cell composition.

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis

This study shows that Piezo2 is essential for mechanical pain sensitization in osteoarthritis, as Piezo2-deficient mice are protected from mechanical hypersensitivity in two models.

HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine

This study shows HOIL1 deficiency in mice causes type 2 inflammation in the small intestine, characterized by increased ILC2 cells and cytokine expression, independent of IL4R signaling.

Using stationary vital rates in impact assessments may underestimate potential threat

This study shows that including temporal trends in vital rates improves PVA accuracy and threat projections for declining populations.