Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19
S. Kamle, B. Ma, C. H. He, B. Akosman, Y. Zhou, C.-M. Lee, W. S. El-Deiry, K. Huntington, O. Liang, J. T. Machan, M.-J. Kang, H. J. Shin, E. Mizoguchi, C. G. Lee, J. A. Elias
This study identifies CHI3L1 as a key mediator of aging-related severity in COVID-19 by stimulating ACE2 and SPP expression, and shows it is a therapeutic target.
bioRxiv · Jan 5, 2021Immunology