Author

C. G. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 4 Cancer Biology· 3 Physiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 13 Research Focus:host-pathogen & immune response· 10 Organism:human· 7 Research Focus:cell type annotation· 5 Assay:metagenomics· 4 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3

Frequent Co-Authors

J. A. Elias· 10 shared S. Kamle· 8 shared B. Ma· 6 shared C.-M. Lee· 6 shared B. Akosman· 5 shared A. Jaitovich· 2 shared C. Vincent· 2 shared G. Schor· 2 shared

Activity by Year

2019-2023 · peak 8/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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10 shared papersImmunology

J. A. Elias

Mutual co-authors in cluster

Author profile →

15 papers

Recent·Most cited

Chitinase 3-like-1 (CHI3L1) Inhibits Innate Anti-Tumor and Tissue Remodeling ImmuneResponses by Regulating CD47-SIRPα and CD24-Siglec10-Mediated Phagocytosis

B. Ma, S. Kamle, C.-M. Lee, J. H. Lee, D. C. Yee, Z. Zhu, E. K. Silverman, D. DeMeo, A. M. K. Choi, C. G. Lee, J. A. Elias

This study shows CHI3L1 inhibits macrophage phagocytosis by modulating CD47-SIRPα and CD24-Siglec10 pathways, contributing to immune evasion in cancer and COPD.

bioRxiv · Dec 27, 2023 · PreprintImmunology

Chitinase 3-like-1 (CHI3L1) in the Pathogenesis of Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer

S. Kamle, B. Ma, G. Schor, M. Bailey, B. Pham, I. Cho, H. Khan, C. Azzoli, M. Hofstetter, C.-M. Lee, R. Herbst, K. Politi, C. G. Lee, J. A. Elias

This study shows CHI3L1 is induced by EGFR activation in NSCLC and promotes EGFR signaling, with anti-CHI3L1 antibodies reversing TKI resistance and inhibiting metastasis.

bioRxiv · Sep 21, 2023Cancer Biology

CHI3L1 Enhances Melanoma Lung Metastasis via Regulation of T cell Co-stimulators and CTLA-4/B7 Axis

B. Ma, S. Kamle, B. Akosman, H. Khan, C.-M. Lee, C. G. Lee, J. A. Elias

This study shows CHI3L1 promotes melanoma lung metastasis by inhibiting T cell co-stimulators and stimulating CTLA-4/B7 axis, with combined anti-CHI3L1 and anti-CTLA-4 antibodies showing synergistic antitumor effects.

bioRxiv · Jun 23, 2022Immunology

Host Chitinase 3-like-1 is a Universal Therapeutic Target for SARS-CoV-2 Viral Variants in COVID 19

S. Kamle, B. Ma, C. M. Lee, G. Schor, Y. Zhou, C. G. Lee, J. A. Elias

This study shows that targeting CHI3L1 inhibits SARS-CoV-2 variants' infection of epithelial cells, suggesting it as a universal therapeutic target.

bioRxiv · Jan 21, 2022Immunology

Chi3l1 is a modulator of glioma stem cell states and a therapeutic vulnerability for glioblastoma

C. Guetta-Terrier, D. Karambizi, B. Akosman, J.-S. Chen, S. Kamle, J. E. Fajardo, A. Fiser, R. Singh, S. A. Toms, C. G. Lee, J. A. Elias, N. Tapinos

This study shows Chi3l1 modulates glioma stem cell states by altering transcription factor activity and cell state transitions, and demonstrates anti-Chi3l1 antibody treatment inhibits glioblastoma growth.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

Dysregulated myogenesis and autophagy in genetically induced pulmonary emphysema

J. Balnis, L. A. Drake, D. V. Singer, C. Vincent, T. C. Korponay, J. M. D'Armiento, C. G. Lee, J. A. Elias, H. A. Singer, A. Jaitovich

This study identifies dysregulated myogenesis and autophagy in COPD-induced muscle dysfunction and shows that autophagy stimulation can improve satellite cell function and myogenesis.

bioRxiv · Jul 8, 2021 · PreprintPhysiology

Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment

Z. Shan, L. Li, C. L. Atkins, M. Wang, Y. Wen, J. Jeong, N. Moreno, D. Feng, X. Gui, N. Zhang, C. G. Lee, J. A. Elias, W. Lee, B. Gao, F. W. Lam, , C. Ju

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

bioRxiv · Apr 8, 2021Pharmacology & Toxicology

Effects of green manure application on soil microbial communities and activities in the decontaminated sandy soil paddy field in Fukushima, Japan

C. G. Lee, Y. Mitsuda, S. Sugihara, T. Ookawa, H. Tanaka

This study examines how green manure decomposition affects soil microbial communities and enzyme activities in a decontaminated sandy soil paddy field in Fukushima, Japan.

bioRxiv · Mar 22, 2021 · PreprintMicrobiology

Kasugamycin is a novel chitinase 1 inhibitor with strong antifibrotic effects on pulmonary fibrosis

J.-H. Lee, C.-M. Lee, J. H. Lee, M.-O. Kim, J. W. Park, S. Kamle, B. Akosman, E. L. Herzog, X. Y. Peng, J. A. Elias, C. G. Lee

This study identifies Kasugamycin as a novel CHIT1 inhibitor with strong antifibrotic effects in pulmonary fibrosis models.

bioRxiv · Feb 25, 2021Immunology

Succinate Dehydrogenase (SDH)-subunit C regulates muscle oxygen consumption and fatigability in an animal model of pulmonary emphysema.

J. Balnis, L. Drake, C. Vincent, T. C. Korponay, D. Singer, D. Lacomis, C. G. Lee, J. Elias, H. A. Singer, A. Jaitovich

The paper investigates the role of SDH subunit C in muscle oxygen consumption and fatigability in an animal model of pulmonary emphysema, finding that SDHC regulates respiration and fiber type composition.

bioRxiv · Jan 22, 2021Physiology

Chitinase 3-like-1 Stimulates PD-L1 and Other Immune Checkpoint Inhibitors

B. Ma, B. Akosman, S. Kamle, C.-M. Lee, J. S. Koo, C. G. Lee, J. A. Elias

This study shows Chi3l1 promotes PD-L1 and other immune checkpoint inhibitors in melanoma, suggesting combined targeting of Chi3l1 and PD-1-PD-L1 as a therapeutic strategy for pulmonary metastasis.

bioRxiv · Jan 15, 2021 · PreprintCancer Biology

Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19

S. Kamle, B. Ma, C. H. He, B. Akosman, Y. Zhou, C.-M. Lee, W. S. El-Deiry, K. Huntington, O. Liang, J. T. Machan, M.-J. Kang, H. J. Shin, E. Mizoguchi, C. G. Lee, J. A. Elias

This study identifies CHI3L1 as a key mediator of aging-related severity in COVID-19 by stimulating ACE2 and SPP expression, and shows it is a therapeutic target.

bioRxiv · Jan 5, 2021Immunology

Soil prokaryotes associated with decreasing pathogen density during anaerobic soil disinfestation

C. G. Lee, T. Iida, E. Kunitomo, K. Nakaho, M. Ohkuma

The paper examines how soil microbial communities change during anaerobic soil disinfestation and identifies specific microbes linked to pathogen reduction.

bioRxiv · Sep 23, 2019Microbiology

Comparison of prokaryotic communities among fields exhibiting different disinfestation effects by anaerobic soil disinfestation

C. G. Lee, T. Iida, E. Matusda, K. Yoshida, M. Kawabe, M. Maeda, H. Watanabe, Y. Muramoto, Y. Otani, K. Nakaho, M. Ohkuma

The paper compares prokaryotic communities in soils with different disinfestation effects after anaerobic soil disinfestation, finding specific microbial changes associated with effective disinfestation.

bioRxiv · Jul 23, 2019 · PreprintMicrobiology

Identification of bacteria involved in the decomposition of lignocellulosic biomass treated with cow rumen fluid by metagenomic analysis

C. G. Lee, Y. Baba, R. Asano, Y. Fukuda, C. Tada, Y. Nakai

bioRxiv · Mar 8, 2019Microbiology