Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells
V. D'Angeli, E. Monzon-Casanova, L. S. Matheson, O. Gizlenci, G. Petkau, C. Gooding, R. V. Berrens, C. W. J. Smith, M. Turner
This study shows PTBP1 is essential for optimal expansion and effector function of antigen-specific CD8 T cells, regulating splicing, mRNA abundance, and NFAT protein nuclear accumulation.
bioRxiv · Mar 3, 2022Immunology