G. Petkau

Zfp36l1 establishes the high affinity CD8 T cell response by directly linking TCR affinity to cytokine sensing

The paper shows ZFP36L1 links TCR affinity to cytokine sensing, promoting clonal expansion of high affinity CD8 T cells through IL2 competition.

MicroRNA-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating stress-independent and dependent expression of IEG and of several myelo/granulopoiesis-enhancing target genes.

This study shows that miR-221/222 in HSC and MPP maintains quiescence and multipotency by suppressing IEGs and myelo/granulopoiesis genes, with implications for improving bone marrow transplants.

Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells

This study shows PTBP1 is essential for optimal expansion and effector function of antigen-specific CD8 T cells, regulating splicing, mRNA abundance, and NFAT protein nuclear accumulation.

The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins

This study identifies ZFP36 and ZFP36L1 as RNA binding proteins that regulate the timing and potency of CD8+ T cell differentiation and effector function during immune response.

Stromal cell-contact dependent PI3K and APRIL induced NF-κB signaling complement each other to prevent mitochondrial- and endoplasmic reticulum stress induced cell death of bone marrow plasma cells

The paper shows that stromal cell contact and APRIL signaling via PI3K and NF-κB pathways prevent mitochondrial and ER stress-induced apoptosis in bone marrow plasma cells.