The variable domain from the mitochondrial fission mechanoenzyme Drp1 promotes liquid-liquid phase separation
A. E. Posey, M. Bagheri, K. A. Ross, E. N. Lanum, M. A. Khan, C. M. Jennings, M. C. Harwig, N. W. Kennedy, V. J. Hilser, J. L. Harden, R. B. Hill
The paper shows the Drp1 variable domain undergoes liquid-liquid phase separation under crowding conditions, which may regulate mitochondrial fission.
bioRxiv · May 29, 2023Biophysics