M. A. Khan

ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression

This study identifies ACSL4 as a driver of TNBC metastasis by enhancing histone acetylation and SNAIL expression through metabolic and epigenetic mechanisms.

Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport

This study shows CLDN2 upregulation during pancreatitis limits disease progression by enhancing tight junction-controlled fluid transport in pancreatic ductal epithelium.

Adaptive therapy achieves long-term control of chemotherapy resistance in high grade ovarian cancer

This study demonstrates that adaptive therapy reduces chemotherapy resistance in ovarian cancer by exploiting fitness costs of resistant cells, extending survival in mice and correlating with disease burden in patients.

The variable domain from the mitochondrial fission mechanoenzyme Drp1 promotes liquid-liquid phase separation

The paper shows the Drp1 variable domain undergoes liquid-liquid phase separation under crowding conditions, which may regulate mitochondrial fission.

PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)

This study shows that PERK inhibition reduces SLC7A11 expression and sensitizes colon cancer cells to ferroptosis, suggesting PERK inhibitors as potential therapeutics.

Habitat suitability modeling of Himalayan Monal and Koklass Pheasant in Western Himalayas and Hindukush, Pakistan

This study models habitat suitability for Himalayan Monal and Koklass Pheasants in Pakistan using MaxEnt and Cringing models, identifying core zones for conservation.

Unfolding the Apoptotic Mechanism of Antioxidant Enriched-Leaves of Tabebuia pallida in EAC Cells

This study investigates the apoptotic effects of Tabebuia pallida extracts on EAC cells using cytotoxicity assays, gene expression analysis, and compound identification.

Cadmium interference with iron sensing reveals transcriptional programs sensitive and insensitive to reactive oxygen species

This study shows cadmium impairs iron sensing in Arabidopsis leaves, inducing iron-deficiency responses even with sufficient iron, suggesting a mechanism beyond root uptake competition.

Exponential Growth of Glioblastoma In Vivo Driven by Rapidly Dividing and Outwardly Migrating Cancer Stem Cells

This study identifies that glioblastoma grows exponentially due to symmetric divisions of brain tumor stem cells (BTSCs) accumulating at the tumor rim.

Developing critical thinking in STEM education through inquiry-based writing in the laboratory classroom

The paper describes an inquiry-based writing (IBW) approach in a bioinformatics course that improves student engagement and learning outcomes through structured scientific writing assignments.

Polymerization Kinetics Stability, Volumetric Changes, Apatite Precipitation, Strontium Release and Fatigue of Novel Bone Composites for Vertebroplasty

This study evaluates the effects of diluent monomers and MCPM on the polymerization kinetics, volumetric stability, apatite precipitation, strontium release, and fatigue properties of novel bone composites for vertebroplasty.