Author

M. C. Harwig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

R. B. Hill· 3 shared K. A. Nolden· 2 shared A. E. Posey· 1 shared B. C. Hofeld· 1 shared C. M. Jennings· 1 shared D. M. Jensen· 1 shared D. Z. Trykall· 1 shared E. N. Lanum· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

R. B. Hill

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The variable domain from the mitochondrial fission mechanoenzyme Drp1 promotes liquid-liquid phase separation

A. E. Posey, M. Bagheri, K. A. Ross, E. N. Lanum, M. A. Khan, C. M. Jennings, M. C. Harwig, N. W. Kennedy, V. J. Hilser, J. L. Harden, R. B. Hill

The paper shows the Drp1 variable domain undergoes liquid-liquid phase separation under crowding conditions, which may regulate mitochondrial fission.

bioRxiv · May 29, 2023Biophysics

Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission

K. A. Nolden, M. C. Harwig, R. B. Hill

This study shows human Fis1 directly interacts with Drp1 to promote mitochondrial fission, a conserved mechanism from yeast.

bioRxiv · May 3, 2023Biochemistry

A novel Fis1 inhibiting peptide reverses diabetic endothelial dysfunction in human resistance arteries

K. A. Nolden, M. Kakarla, J. M. Egner, J. Wang, M. C. Harwig, V. K. Puppala, B. C. Hofeld, L. A. Arnold, D. Z. Trykall, F. C. Peterson, M. L. Roberts, D. M. Jensen, R. B. Hill, M. E. Widlansky

This study shows that inhibiting Fis1 improves endothelial function in diabetic vessels by enhancing NO availability and reducing mitochondrial ROS.

bioRxiv · Nov 16, 2020 · PreprintPhysiology