Author

E. N. Shirk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:non-human primate· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

S. E. Queen· 3 shared B. Carlson· 2 shared J. M. Izzi· 2 shared K. W. Witwer· 2 shared O. Gololobova· 2 shared A. Maxwell· 1 shared B. Bullock· 1 shared B. Smith· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

S. E. Queen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood

B. V. Rodriguez, Y. Wen, E. N. Shirk, S. Vazquez, O. Gololobova, A. Maxwell, J. Plunkard, N. V. Castell, B. Carlson, S. E. Queen, J. M. Izzi, T. A. P. Driedonks, K. W. Witwer

This study develops an ex vivo model to study EV-blood cell interactions in whole blood from pig-tailed macaques, showing EVs preferentially associate with B cells.

bioRxiv · May 11, 2023 · PreprintImmunology

Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

T. Driedonks, L. Jiang, B. Carlson, Z. Han, G. Liu, S. E. Queen, E. N. Shirk, O. Gololobova, L. H. Nyberg, G. Lima, L. Paniushkina, M. Garcia-Contreras, K. Schonvisky, M. Stover, S. Guerrero-Martin, , K. W. Witwer

This study investigates the pharmacokinetics and biodistribution of extracellular vesicles in macaques via intravenous and intranasal routes, finding longer plasma circulation times and organ uptake with IV administration, but limited systemic distribution with IN.

bioRxiv · Jul 28, 2021Pharmacology & Toxicology

Social Stress Alters Immune Response and Results in Higher Viral Load During Acute SIV Infection in a Pigtailed Macaque Model of HIV

S. M. Guerrero-Martin, L. H. Rubin, K. M. Mcgee, E. N. Shirk, S. E. Queen, M. Li, B. Bullock, B. W. Carlson, R. J. Adams, L. Gama, D. Graham, C. Zink, J. E. Clements, J. L. Mankowski, K. A. Metcalf Pate

This study shows that social stress in SIV-infected macaques increases viral load and T cell activation during acute infection compared to socially housed animals.

bioRxiv · Apr 21, 2020 · PreprintMicrobiology