Author

K. W. Witwer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:benchmarking· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:non-human primate· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

O. Gololobova· 5 shared B. Smith· 3 shared A. Pekosz· 2 shared B. Carlson· 2 shared E. N. Shirk· 2 shared G. Lima· 2 shared J. M. Izzi· 2 shared L. Jiang· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersImmunology

O. Gololobova

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood

B. V. Rodriguez, Y. Wen, E. N. Shirk, S. Vazquez, O. Gololobova, A. Maxwell, J. Plunkard, N. V. Castell, B. Carlson, S. E. Queen, J. M. Izzi, T. A. P. Driedonks, K. W. Witwer

This study develops an ex vivo model to study EV-blood cell interactions in whole blood from pig-tailed macaques, showing EVs preferentially associate with B cells.

bioRxiv · May 11, 2023 · PreprintImmunology

miR-210 expression is strongly hypoxia-induced in anaplastic thyroid cancer cell lines and is associated with extracellular vesicles & Argonaute-2

B. H. Powell, A. Turchinovich, Y. Wang, O. Gololobova, D. Buschmann, M. A. Zeiger, C. B. Umbricht, K. W. Witwer

The paper investigates miR-210-3p as a hypoxia marker in anaplastic thyroid cancer cells, showing its expression under low oxygen conditions and association with extracellular vesicles and AGO2.

bioRxiv · Nov 23, 2022Cancer Biology

Longitudinal characterization of circulating extracellular vesicles and small RNA during simian immunodeficiency virus infection and antiretroviral therapy

Y. Huang, Z. Liao, P. Dang, S. Queen, C. M. Abreu, L. Zheng, K. W. Witwer

This study tracks changes in extracellular vesicle concentration and small RNA expression during SIV infection and ART in macaques, identifying dynamic shifts in miRNAs and U6 RNA associated with viral load.

bioRxiv · Sep 4, 2022Microbiology

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

M. Chen, A. Pekosz, J. Villano, W. Shen, R. Zhou, H. Kulaga, Z. Li, S. E. Beck, K. W. Witwer, J. Mankowski, M. Ramanathan, N. Rowan, A. Lane

This study examines how SARS-CoV-2 variants infect nasal and olfactory tissues, showing differences in tropism, immune response, and regeneration across age groups.

bioRxiv · Apr 12, 2022Pathology

Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

T. Driedonks, L. Jiang, B. Carlson, Z. Han, G. Liu, S. E. Queen, E. N. Shirk, O. Gololobova, L. H. Nyberg, G. Lima, L. Paniushkina, M. Garcia-Contreras, K. Schonvisky, M. Stover, S. Guerrero-Martin, , K. W. Witwer

This study investigates the pharmacokinetics and biodistribution of extracellular vesicles in macaques via intravenous and intranasal routes, finding longer plasma circulation times and organ uptake with IV administration, but limited systemic distribution with IN.

bioRxiv · Jul 28, 2021Pharmacology & Toxicology

A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant

L. Jiang, T. Driedonks, M. Lowman, W. S. Jong, H. B. van den Berg van Saparoea, S. Dhakal, R. Zhou, C. Caputo, K. Littlefield, I. Sitaras, M. W. Chen, G. Lima, O. Gololobova, B. Smith, V. Mahairaki, , K. W. Witwer

bioRxiv · Jun 28, 2021Immunology

Characterization of extracellular vesicles and artificial nanoparticles with four orthogonal single-particle analysis platforms

T. Arab, E. R. Mallick, Y. Huang, L. Dong, Z. Liao, Z. Zhao, O. Gololobova, B. Smith, N. J. Haughey, K. J. Pienta, B. S. Slusher, P. M. Tarwater, J. P. Tosar, A. M. Zivkovic, W. N. Vreeland, , K. W. Witwer

This study compares four single-particle analysis platforms for sizing, counting, and phenotyping extracellular vesicles and synthetic particles, identifying differences in performance across modalities.

bioRxiv · Aug 4, 2020Cell Biology