Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes
M. Gutierrez-Gonzalez, A. S. Fahad, M. Ardito, P. Nanaware, L. Lu, E. Normandin, B. Madan, J. Tivin, E. Coates, A. R. Henry, F. Laboune, B. S. Graham, D. C. Douek, J. E. Ledgerwood, J. R. Mascola, , B. J. DeKosky
The paper shows that MHC-II epitope removal from BCRs correlates with antibody development, T cell help, and long-term serum antibody secretion.
bioRxiv · Jan 15, 2021 · PreprintImmunology