Author

B. Madan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2

Frequent Co-Authors

B. J. DeKosky· 5 shared A. S. Fahad· 4 shared S. N. Lopez Acevedo· 4 shared I.-T. Teng· 3 shared J. R. Mascola· 3 shared M. Oliveira de Souza· 3 shared N. P. Harmston· 3 shared P. D. Kwong· 3 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersImmunology

B. J. DeKosky

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling

B. Madan, S. R. Wadia, S. Patnaik, N. P. Harmston, E. J. Tan, I. B. Tan, D. W. Nes, E. G. Petretto, D. M. Virshup

This paper identifies FAXDC2 as a cholesterol biosynthesis enzyme that links Wnt/beta-catenin to RTK/MAPK signaling, showing its role in cancer progression and cellular differentiation.

bioRxiv · Dec 15, 2023Cancer Biology

Immortalization and Functional Screening of Natively Paired Human T Cell Receptor Repertoires

A. S. Fahad, C. Yu Chung, S. N. Lopez Acevedo, N. Boyle, B. Madan, M. F. Gutierrez-Gonzalez, R. Matus-Nicodemos, A. D. Laflin, R. R. Ladi, J. Zhou, J. Wolfe, S. Llewellyn-Lacey, D. Doueck, H. H. Balfour, D. A. Price, B. J. DeKosky

The paper develops a high-throughput method to functionally evaluate natively paired human T cell receptors against multiple pMHCs, validated through affinity-based mapping and sequencing.

Protein Engineering, Design and Selection · Feb 17, 2022Peer-reviewedImmunology

Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron

I.-T. Teng, A. F. Nazzari, M. Choe, T. Liu, M. Oliveira de Souza, Y. Petrova, Y. Tsybovsky, S. Wang, B. Zhang, M. Artamonov, B. Madan, A. Huang, S. N. Lopez Acevedo, X. Pan, T. J. Ruckwardt, , P. D. Kwong

The paper designs and produces molecular probes for SARS-CoV-2 variants to assess immune responses and isolate neutralizing antibodies.

bioRxiv · Dec 29, 2021 · PreprintImmunology

Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes

M. Gutierrez-Gonzalez, A. S. Fahad, M. Ardito, P. Nanaware, L. Lu, E. Normandin, B. Madan, J. Tivin, E. Coates, A. R. Henry, F. Laboune, B. S. Graham, D. C. Douek, J. E. Ledgerwood, J. R. Mascola, , B. J. DeKosky

The paper shows that MHC-II epitope removal from BCRs correlates with antibody development, T cell help, and long-term serum antibody secretion.

bioRxiv · Jan 15, 2021 · PreprintImmunology

Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

B. B. Banach, G. Cerutti, A. S. Fahad, C.-H. Shen, M. Oliveira de Souza, P. S. Katsamba, Y. Tsybovsky, P. Wang, M. S. Nair, Y. Huang, I. M. Francino Urdaniz, P. J. Steiner, M. Gutierrez-Gonzalez, L. Liu, S. N. Lopez Acevedo, , B. J. DeKosky

This study identifies a public antibody class, IGHV3-53/3-66, with potent SARS-CoV-2 neutralization capabilities through paired heavy and light chain interactions.

bioRxiv · Dec 31, 2020Immunology

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

T. Zhou, I.-T. Teng, A. S. Olia, G. Cerutti, J. Gorman, A. Nazzari, W. Shi, Y. Tsybovsky, L. Wang, S. Wang, B. Zhang, Y. Zhang, P. S. Katsamba, Y. Petrova, B. B. Banach, , P. D. Kwong

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

bioRxiv · Jun 22, 2020Immunology

WNT inhibition creates a BRCA-like state in Wnt-addicted cancer

A. Kaur, S. Sepramaniam, J. Y. S. Lim, S. Patnaik, N. P. HARMSTON, M. A. Lee, E. G. Petretto, D. Virshup, B. Madan

The paper shows that Wnt inhibition creates a BRCA-like state in Wnt-addicted cancers, enhancing sensitivity to DNA damage.

bioRxiv · Jun 17, 2020Cancer Biology

The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity

J. Yu, P. A. Bt Mohamed Yuso, P. Goh, N. P. HARMSTON, D. Epstein, D. M. Virshup, B. Madan

This study identifies RNF43 mutations that predict sensitivity to Wnt inhibitors by analyzing their functional impact in vitro and in vivo.

bioRxiv · Mar 25, 2020 · PreprintCancer Biology