Author

A. S. Fahad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

B. J. DeKosky· 4 shared B. Madan· 4 shared S. N. Lopez Acevedo· 3 shared A. D. Laflin· 2 shared A. Nazzari· 2 shared A. S. Olia· 2 shared B. B. Banach· 2 shared B. S. Graham· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersImmunology

B. J. DeKosky

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Author profile →

4 papers

Recent·Most cited

Immortalization and Functional Screening of Natively Paired Human T Cell Receptor Repertoires

A. S. Fahad, C. Yu Chung, S. N. Lopez Acevedo, N. Boyle, B. Madan, M. F. Gutierrez-Gonzalez, R. Matus-Nicodemos, A. D. Laflin, R. R. Ladi, J. Zhou, J. Wolfe, S. Llewellyn-Lacey, D. Doueck, H. H. Balfour, D. A. Price, B. J. DeKosky

The paper develops a high-throughput method to functionally evaluate natively paired human T cell receptors against multiple pMHCs, validated through affinity-based mapping and sequencing.

Protein Engineering, Design and Selection · Feb 17, 2022Peer-reviewedImmunology

Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes

M. Gutierrez-Gonzalez, A. S. Fahad, M. Ardito, P. Nanaware, L. Lu, E. Normandin, B. Madan, J. Tivin, E. Coates, A. R. Henry, F. Laboune, B. S. Graham, D. C. Douek, J. E. Ledgerwood, J. R. Mascola, , B. J. DeKosky

The paper shows that MHC-II epitope removal from BCRs correlates with antibody development, T cell help, and long-term serum antibody secretion.

bioRxiv · Jan 15, 2021 · PreprintImmunology

Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

B. B. Banach, G. Cerutti, A. S. Fahad, C.-H. Shen, M. Oliveira de Souza, P. S. Katsamba, Y. Tsybovsky, P. Wang, M. S. Nair, Y. Huang, I. M. Francino Urdaniz, P. J. Steiner, M. Gutierrez-Gonzalez, L. Liu, S. N. Lopez Acevedo, , B. J. DeKosky

This study identifies a public antibody class, IGHV3-53/3-66, with potent SARS-CoV-2 neutralization capabilities through paired heavy and light chain interactions.

bioRxiv · Dec 31, 2020Immunology

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

T. Zhou, I.-T. Teng, A. S. Olia, G. Cerutti, J. Gorman, A. Nazzari, W. Shi, Y. Tsybovsky, L. Wang, S. Wang, B. Zhang, Y. Zhang, P. S. Katsamba, Y. Petrova, B. B. Banach, , P. D. Kwong

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

bioRxiv · Jun 22, 2020Immunology