Repurposing host-guest chemistry to sequester virulence and eradicate biofilms in multidrug resistant Pseudomonas aeruginosa and Acinetobacter baumannii
C. Jonkergouw, N. K. Beyeh, E. Osmekhina, K. Leskinen, S. M. Taimoory, D. Fedorov, E. Anaya-Plaza, M. A. Kostiainen, J. F. Trant, R. H. A. Ras, P. Saavalainen, M. B. Linder
This paper identifies Pillar[5]arene, a synthetic macrocycle that targets virulence factors in multidrug-resistant bacteria, reducing biofilms and enhancing antibiotic efficacy.
bioRxiv · Mar 1, 2023 · PreprintBiochemistry