Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes
B. Navarro-Serer, E. P. Childers, N. M. Hermance, D. Mercadante, A. L. Manning
This study shows Aurora A inhibition disrupts spindle pole clustering in cells with supernumerary centrosomes, leading to mitotic catastrophe and aneuploid daughter cells.
bioRxiv · Feb 2, 2019Cancer Biology