The glutathione S-transferase Gstt1 is a robust driver of survival and dissemination in metastases
C. M. Ferrer, R. Boon, H. Cho, T. Bernasocchi, L. P. Wong, M. Cetinbas, E. R. Haggerty, I. Mitsiades, G. R. Wojtkiewicz, D. E. McLoughlin, S. Kugel, E. Rheinbay, R. Sadreyev, D. Juric, R. Mostoslavsky
This study identifies Gstt1 as a critical driver of metastasis and dissemination in pancreatic cancer, showing its role in maintaining metastatic lesions and influencing the tumor microenvironment.
bioRxiv · Sep 10, 2022 · PreprintCancer Biology