Author

R. Sadreyev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

L. P. Wong· 3 shared M. Cetinbas· 3 shared F. Adiliaghdam· 2 shared H. Amatullah· 2 shared K. L. Jeffrey· 2 shared S. Digumarthi· 2 shared A. Anselmo· 1 shared A. K. Scherer· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

L. P. Wong

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Nuclear autophagy interactome unveils WSTF as a constitutive nuclear inhibitor of inflammation

Y. Wang, V. V. Eapen, A. Kournoutis, A. Onorati, X. Li, X. Zhou, M. Cetinbas, L. Wang, J. Liu, C. Bretz, Z. Zhou, S. J. Ho Sui, S. V. Saladi, R. Sadreyev, P. D. Adams, , Z. Dou

The paper identifies WSTF as a nuclear inhibitor of inflammation degraded by autophagy, showing its role in inflammation, cancer, and immune surveillance.

bioRxiv · Oct 4, 2022Cell Biology

The glutathione S-transferase Gstt1 is a robust driver of survival and dissemination in metastases

C. M. Ferrer, R. Boon, H. Cho, T. Bernasocchi, L. P. Wong, M. Cetinbas, E. R. Haggerty, I. Mitsiades, G. R. Wojtkiewicz, D. E. McLoughlin, S. Kugel, E. Rheinbay, R. Sadreyev, D. Juric, R. Mostoslavsky

This study identifies Gstt1 as a critical driver of metastasis and dissemination in pancreatic cancer, showing its role in maintaining metastatic lesions and influencing the tumor microenvironment.

bioRxiv · Sep 10, 2022 · PreprintCancer Biology

Effectors enabling adaptation to mitochondrial complex I loss in Hurthle cell carcinoma

R. K. Gopal, V. R. Vantaku, A. Panda, B. Reimer, S. Rath, T.-L. To, A. S. Fisch, M. Cetinbas, M. Livneh, M. J. Calcaterra, B. Gigliotti, K. Pierce, C. B. Clish, D. Dias-Santagata, P. M. Sadow, , V. Mootha

This study identifies molecular effectors in Hurthle cell carcinoma linked to mitochondrial complex I loss, highlighting lipid peroxide scavenging as a therapeutic vulnerability.

bioRxiv · Aug 16, 2022Cancer Biology

Human enteric viruses shape disease phenotype through divergent innate immunomodulation

F. Adiliaghdam, H. Amatullah, S. Digumarthi, T. L. Saunders, R.-U. Rahman, L. P. Wong, R. Sadreyev, L. Droit, J. Paquette, P. Goyette, J. Rioux, R. Hodin, K. Mihindukulasuriya, S. A. Handley, K. L. Jeffrey

The paper shows that human viromes from healthy and IBD patients differentially modulate innate immunity, influencing disease phenotypes through nucleic acid sensing.

bioRxiv · Oct 14, 2021 · PreprintImmunology

Identification of topoisomerase as a precision-medicine target in chromatin reader SP140-driven Crohns disease

H. Amatullah, S. Digumarthi, I. Fraschilla, F. Adiliaghdam, G. Bonilla, L. P. Wong, R. Sadreyev, K. L. Jeffrey

This study identifies SP140 as a repressor of topoisomerases in immune diseases and shows TOP inhibition can reverse SP140-driven pathology.

bioRxiv · Sep 20, 2021 · PreprintImmunology

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Y. Kfoury, F. Ji, M. Mazzola, D. B. Sykes, A. K. Scherer, A. Anselmo, Y. Akiyama, F. Mercier, N. Severe, K. D. Kokkaliaris, T. Brouse, J. Seidl, A. Papzian, P. Ivanov, M. K. Mansour, , D. T. Scadden

The paper shows that stress-induced extracellular vesicles transfer tiRNAs to hematopoietic progenitors, enhancing myeloid recovery and survival.

bioRxiv · Apr 13, 2021Cell Biology