Role of UCP2 in the energy metabolism of the cancer cell line A549
J. Segales, C. Sanchez-Martin, A. Pujol, M. Martin-Ruiz, E. Rial
This study investigates the role of UCP2 in A549 cancer cells, finding that UCP2 silencing reduces respiration without increasing glycolysis and does not alter ATP levels or proton leakage, suggesting UCP2 functions as a C4-metabolite carrier rather than an uncoupling protein.
bioRxiv · Sep 13, 2022 · PreprintBiochemistry