Soluble guanylate cyclase stimulation mitigates skeletal and cardiac muscle dysfunction in a mdx model of Duchenne muscular dystrophy
L. Zhang, Y. Xu, K. Yousefi, C. I. Irion, R. A. Alvarez, S. M. Krishnan, J.-P. Stasch, E. C. Martinez, E. S. Buys, P. Sandner, L. A. Shehadeh, J. M. Percival
This study shows that stimulating soluble guanylate cyclase (sGC) with BAY41-8543 reduces skeletal and cardiac muscle dysfunction in mdx mice, suggesting sGC as a therapeutic target for Duchenne muscular dystrophy.
bioRxiv · Feb 14, 2021 · PreprintPhysiology