Author

R. A. Alvarez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. K. Chen· 2 shared C. E. Hioe· 2 shared C. Upadhyay· 2 shared M. Calvo· 2 shared M. I. Barria· 2 shared N. Satija· 2 shared A. F. Tang· 1 shared A. Finzi· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

B. K. Chen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

M. A. Medina, F. Fuentes-Villalobos, C. Quevedo, F. Aguilera, R. Riquelme, M. L. Rioseco, S. Barria, Y. Pinos, M. Calvo, I. Burbulis, C. Kossack, R. A. Alvarez, J. L. Garrido, M. I. Barria

The paper identifies genes from the natural killer cell-mediated cytotoxicity pathway as critical in determining clinical outcomes of COVID-19 by analyzing longitudinal transcriptional changes in immune cells.

bioRxiv · Jan 2, 2024Immunology

Humoral immune responses against seasonal coronaviruses predict efficiency of SARS-CoV-2 spike targeting, FcγR activation, and corresponding COVID-19 disease severity

J. J. Garrido, M. Medina, F. Bravo, S. McGee, F. Fuentes, M. Calvo, J. W. Bowman, C. D. Bahl, M. I. Barria, R. A. Brachman, R. A. Alvarez

The paper shows that humoral immune responses against seasonal coronaviruses correlate with SARS-CoV-2 disease severity and antibody targeting of specific epitopes.

bioRxiv · Sep 14, 2021 · PreprintMicrobiology

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice

C. E. Hioe, G. Li, X. Liu, O. Tsahouridis, X. He, M. Funaki, J. Klingler, A. F. Tang, R. Feyznezhad, D. W. Heindel, X.-H. Wang, D. A. Spencer, G. Hu, N. Satija, J. Prevost, , L. Su

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.

bioRxiv · May 24, 2021Immunology

Soluble guanylate cyclase stimulation mitigates skeletal and cardiac muscle dysfunction in a mdx model of Duchenne muscular dystrophy

L. Zhang, Y. Xu, K. Yousefi, C. I. Irion, R. A. Alvarez, S. M. Krishnan, J.-P. Stasch, E. C. Martinez, E. S. Buys, P. Sandner, L. A. Shehadeh, J. M. Percival

This study shows that stimulating soluble guanylate cyclase (sGC) with BAY41-8543 reduces skeletal and cardiac muscle dysfunction in mdx mice, suggesting sGC as a therapeutic target for Duchenne muscular dystrophy.

bioRxiv · Feb 14, 2021 · PreprintPhysiology

P2X1 selective antagonists block HIV-1 infection through inhibition of envelope conformation-dependent fusion

A. Y. Soare, H. S. Malik, N. Durham, T. L. Freeman, R. A. Alvarez, F. Patel, N. Satija, C. Upadhyay, C. E. Hioe, B. K. Chen, T. H. Swartz

This paper shows P2X1 antagonists block HIV-1 infection by inhibiting envelope conformation-dependent fusion across multiple viral clades.

bioRxiv · Sep 26, 2019Microbiology