Activation of 2,4-diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a putative dioxygenase
E. Melief, S. A. Bonnett, E. S. Zuniga, T. Parish
The paper shows that Rv3161c in M. tuberculosis metabolizes diaminoquinazolines, as evidenced by the presence of the parent compound in a mutant strain and a mono-hydroxylated metabolite in the wild-type.
bioRxiv · Jul 24, 2018Microbiology